# Verteporfin project — index

Start here: `CLAUDE.md` for the full plan.
For the synthesis output, jump to `FINDINGS.md` and `RECONCILIATION.md`.

## Top-level synthesis (start here, in this order)
- **`CRITIQUE.md`** — the harsh read: what's wrong with the chat's epistemics, the published evidence, and the prior outputs. Read this first.
- **`CORRECTIONS-V2.md`** — change log: every error found in v1 outputs and how it was fixed.
- **`RECONCILIATION.md`** — every chat claim cross-checked against literature (with v2 corrections).
- **`FINDINGS.md`** — what we know now, what we don't.

(Earlier versions of `FINDINGS.md` and `RECONCILIATION.md` were too charitable;
the corrections are dated.)

## Source data
- `drafts/breif-notes.txt` — user's prior notes
- `telegram/` — raw export (gitignored, private)
- `raw-extracted/messages.json` — parseable JSON (3200 msgs; original was truncated)
- `raw-extracted/all-messages-chronological.md` — single-file chronological dump
- `raw-extracted/by-topic/` — 22 files (Off-Topic = 2068, Mental_Health = 426)
- `raw-extracted/by-person/` — 22 files

## Phase A — Telegram opinions

### A.1 Per-poster profiles (`profiles/`)
- `_MASTER.md` — roster + headline finding
- `Daisey.md`, `Enrico.md`, `silk_thread.md`, `George_Kal.md`,
  `German_Cherdakli.md`, `Masha_C.md`, `Barfy_Jones.md`, `S_S.md` — heavy contributors
- `_minor.md` — André, P, Kenby Papaya, Wolfie, martha Halli, Woot, Gina G,
  bert, Cultural Dust, Fabio, Jack Nl, Ragnar, N G, Alex Zapata, **K K**

### A.2 Cross-cut by topic (`by-topic/`)
- `_INDEX.md` — file roster + cleanest finding per file
- `who-actually-tried-it.md` — short list of every documented VP self-experiment
- `dosing.md`, `formulation.md`, `application-method.md`, `timing.md`
- `outcomes.md`, `side-effects.md`, `sourcing.md`
- `doctors.md` — chat's view of each doctor (independent verification in research/)
- `mechanism-and-theories.md`, `disagreements.md`, `open-questions.md`
- `mental-health-context.md` — psychological weight of scarring (German, silk thread, Daisey, others)

## Phase B — Independent literature

### Verteporfin (`research/verteporfin/`)
- `mechanism.md` — YAP/TAZ, light-independent inhibition, En1+ fibroblasts
- `animal-studies.md` — Mascharak 2021 mouse + 2025 pig; dose-volume specifics
- `human-evidence.md` — n=3+1 off-label; SCARFREE-001 (NCT07488988) + NCT06944249
- `dose-response.md` — community 0.8 mg/cm² anchor vs published n=3
- `safety.md` — Visudyne label; novel depigmentation reports
- `formulations.md` — Visudyne (DMPC:EPG 3:5); DIY lecithin; DMSO; hydrogel
- `doctors.md` — Bloxham, Bargouthi, Qazi, Krishna, Carneiro, Toyos, Yang Liu, Longaker/Mascharak
- `_OPEN-QUESTIONS.md`

### Other scar techniques (`research/scar-techniques/`)
- `_OVERVIEW.md` — comparison table across all 9 techniques
- **Ablative / cutting**: `microcoring.md`, `tca-cross.md`, `fractional-laser.md`,
  `subcision.md`, `surgical-revision.md`
- **Medical / topical / emerging**: `microneedling.md`, `silicone-pressure.md`,
  `intralesional.md`, `emerging.md` (embrace device, Sirnaomics, avotermin failure, etc.)

## Roster snapshot

```
 860  Daisey               (mental-health voice; no VP)
 533  Enrico               (admin, protocol drafter; no VP)
 453  silk thread          (mental-health voice; no VP; Qazi $9k declined)
 409  George Kal           (planning pico+VP for stretch marks)
 304  German Cherdakli     (RFMN for chickenpox; no VP)
 170  Masha C              (microneedling 2.5mm + 23% lido; CO₂ laser)
  72  Barfy Jones          (planning hairline advancement +VP 1.0-1.2)
  52  S S                  (planning facial excision +VP 0.8)
 ≤22  others — including K K (only completed self-exp, 0.4 mg/cm²)
```

Referenced (not in chat): Lucy, Sage, Ivy, Dr Bloxham, Dr Bargouthi, Dr Qazi,
Dr Yang Liu, Dr Rohit Krishna, Fabio Carneiro, Longaker / Mascharak / Gurtner.

## Stats

- ~7900 lines of structured md output across 41 files
- 22 chat posters profiled; 4 documented VP self-experiments (1 in chat, 3 referenced)
- 7 doctor profiles independently verified; 4 chat doctor-claims overturned

## Next phases (deferred)
- Webapp (per CLAUDE.md Phase C)
- Continued profile updates if user gets more recent Telegram archive
- Outcome on George Kal's experiment if he reports back post-Aug 28