Cryonics posts — 2026-04-24
Two Substack draft posts drafted after a meeting with Nectome in Portland on 2026-04-23. Both drafts have gone through an AI fact-check pass; see the review reports for a list of flagged claims, citation errors, and missing counterarguments. Nothing here has been personally verified by the author beyond spot-checks — treat as research-quality, not publication-quality.
Post 1 — Why are humans (not) solid?
Biochemistry of aldehyde fixation. Egg vs. body composition, glutaraldehyde mechanism, endogenous aldehyde chemistry in cell death.
- draftWhy are humans (not) solid?Substack-style synthesis draft
- researchResearch note 01 — Egg vs human body compositionSupporting research notes
- researchResearch note 02 — Aldehyde fixation chemistrySupporting research notes
- researchResearch note 03 — Endogenous aldehyde chemistry and the "death-is-partial-ASC" hypothesisSupporting research notes
- researchSources — Post 1: Why are humans (not) solid?Source URL list
- reviewFact-check: "Why are humans (not) solid?"Citation audit, flagged errors, steelman
Post 2 — The real bottleneck in brain preservation is not the cryoprotectant
Cerebral capillaries, no-reflow, ICP, CPA perfusion, scan modality as epistemic trap, ischemic factors, cooling physics.
- draftThe real bottleneck in brain preservation is not the cryoprotectantSubstack-style synthesis draft
- researchHemodynamics and capillariesSupporting research notes
- researchIntracranial pressure, brain shrinkage, and the skull constraintSupporting research notes
- researchCryoprotectant perfusion failure modesSupporting research notes
- researchScan modality and quality evaluationSupporting research notes
- researchCatalogue of ischemic injury factorsSupporting research notes
- researchCooling physicsSupporting research notes
- researchSources consultedSource URL list
- reviewFact-check: "The real bottleneck in brain preservation is not the cryoprotectant"Citation audit, flagged errors, steelman
Project meta
Context for the two posts.
- Cryonics Posts — 2026-04-24 Nectome Meeting OutgrowthProject plan and meeting context