A unified index across body composition, hair, skin, voice, HRT, surgeries, and the medical context. Pulls together notes scattered across darkarts.wiki, trans-surgeries, looksmaxxing, diy-lab-testing, post-surgery-recovery, and associated-traits.
Energy balance under estradiol, fat redistribution methods, and the long catalog of compounds and procedures that move fat where you want it.
The MtF gain phase — estradiol-driven fat bias, HRT body-comp changes, practical surplus guidance, alcohol caveats, and where the evidence runs out.
Diets, anti-obesity meds, and supplements for keeping a cut going — effect sizes, regain, structure, and hype.
Liposuction, cryolipolysis, DCA, HIFU, lasers, RF, topicals, PAH risk, and the methods that survived a critical pass.
Compound and method list for selective fat redistribution, organised by function (adipocyte death, lipolysis stimulation) and flat evidence rank.
The other side — putting fat on selectively. Estradiol patterning, genistein/aromatase notes, fat grafting context.
The peptide-promiscuous fat-killer — what the original primate work showed, what the human pilots said, and why it stalled.
The whole growth-hormone-axis class — tesamorelin, MK-677, sermorelin, CJC-1295/ipamorelin, GHRPs, IGF-1 LR3 — sized honestly against what T plus lifting already delivers. With the cancer/IGF-1 risk argument and the peptide-vendor reality.
Loss, removal, and styling — the three problems. Treatments ranked by effect size, with serious attention to laser physics, electrolysis modalities, and AGA biology.
AGA genetics, 5-AR biology, approved treatments, procedures, the AA/TE/scarring branches, and the pipeline.
Laser wavelengths and Fitzpatrick matrix, electrolysis, eflornithine, systemic pharmacology, trans peri-op clearance, PFB & HS, ocular safety.
Hierarchical index — laser-deep (wavelengths, physics, populations, complications), electrolysis-deep (galvanic / thermolysis / blend, probes, machines, parameters), shortterm-deep (shaving, depilation, waxing, sugaring, threading), community insights, cost & cadence.
Galvanic, thermolysis, blend — the modalities, the finisher role after laser, and what determines clearance.
What hurts, why, and the analgesia stack — topical, systemic, and procedural mitigation.
Cuts, products, and density-management strategies that visually carry a feminine head shape.
Timing, monitoring, and the DIY infrastructure for verifying what you put in your body.
Half-lives, dosing schedules, and what changes day-over-day vs. cycle-over-cycle. Practical timing for stable serum levels.
The E₁S reservoir question, properly sourced. Ruder 1972 ρ = 0.014, Doll 2022 trans-women PK, ENIGI estrone-vs-breast null, and a public audit of 13 unsourced chat claims (5 confirmed, 4 refined, 3 refuted).
Chronological deep dive: Doisy 1929 → Schachter & Marrian 1938 → Ruder 1972 → STS gene cloning 1987 → Tebbens 2022. 91 quote files, every paper verified, contestation noted, community lore audited. Includes the full table of every human E₁S administration study.
Community testing of self-sourced HRT & peptides — 11 lab profiles, runnable HPLC + oil-LLE LAL SOPs, endotoxin kit shootout, used-HPLC checklist, aggregate stats across 6,800+ Finnrick samples.
Three cross-linked documents: tight synthesis with inline C1–C5 confidence tags on every claim, evidence appendix with 64 direct source quotes + primary-data figures, and a reference glossary covering 13 chemical structures + 26 enzymes + 43 key papers. Rebuilt after three rounds of independent fact-check (Claude + GPT/codex).
The folder behind the synthesis. v4 ODE model (12 scenarios, 10/12 within 2× of literature anchors), Sankey flux diagrams, interactive time-animation viewer, fact-check reports, and the original AI conversation that started it all.
Hormonal foundations, PDE5 / melanocortin pharmacology, dampener side-effects of HRT components, refractory-period biology, and trans-specific patterns.
Eight deep dives: hormones, PDE5 inhibitors, melanocortin (PT-141), refractory period & prolactin, dampeners, progestins, trans-specific patterns, and missed topics (flibanserin, kisspeptin, dopamine).
How androgens, estrogens, and SHBG actually drive desire and arousal. Where the canonical model falls apart.
What estradiol monotherapy, anti-androgens, and progestins actually do to desire — patterns from community data and the literature.
The surgeon database, decision-making for procedure selection, and what to do after.
UI for Reddit data — 850+ surgeons across 6 procedure types with 8,966 evidence links. Searchable by procedure, country, and outcome notes.
Facial Feminization — surgeon listings, technique notes, outcomes by region.
Voice Feminization Surgery — Yeson VFSRAC, glottoplasty, CTA, surgeon comparisons, recovery timelines.
Sex Reassignment Surgery — vaginoplasty techniques, surgeon comparisons, complications and revision data.
Implant types, placement, sizing — and the literature on transfemme-specific outcomes.
Fat transfer (BBL), implants, and 360° contouring — what works for transfemme silhouettes.
FUE/FUT, hairline lowering, eyebrow transplants. Surgeon listings and outcome notes from the community.
Supplements, peptides, and VFSRAC-specific protocols for optimal healing. Master guide, products list, shopping list, Korea sourcing guide.
The single canonical recovery write-up — phases, supplement stack, Korea-pharmacy pipeline, scar-free healing research.
What to actually look for in Korean stores — packaging, brands, identifying authentic supplements at the pharmacy counter.
Concrete buy-this-now list of supplements / topicals / dressings, with quantities per recovery phase.
Where to actually buy each item in Korea — pharmacy chain coverage, OTC vs. Rx, neighborhoods near surgery clusters.
Conditions associated with gender dysphoria — what to flag for your GP, what to keep watch for, and how the cluster maps onto the broader comorbidity literature.
Medical conditions associated with gender dysphoria — connective tissue, neurodivergence, autoimmune. With sources and prevalences.
ESR1/ESR2 polymorphisms and downstream signaling differences in the cohort.
CYP / COMT pathways for catecholestrogen handling and where the bottlenecks sit.
The Met/Met variant — anxiety, catecholamine clearance, and the trans-leaning phenotype.
Non-classic congenital adrenal hyperplasia — 21-hydroxylase deficiency, ACTH stim screening, why it shows up here.
Coital role discordance and the cluster of associated phenotypes flagged in the original paper.
Including the Hashimoto’s “double-line sign” pattern and elevated cohort prevalence.
Cohort prevalence, dysphoria/zinc anecdotes, supplementation evidence.
Receptor polymorphisms, sun exposure patterns, and why the labs run low here.
Primer for reading the genetics elsewhere on the wiki — variants, zygosity, sequencing routes.
Reddit posts and case discussions saved on the wiki — including the “nonad of trans,” mystery-illness updates, and the genome-browser pieces.
Local mirror of blog.darkarts.wiki — every Substack post saved offline, indexed by topic.