serotoinin

// TODO Serotonin

Insulin resistance

Insomnia

https://jcsm.aasm.org/doi/10.5664/jcsm.10158

1) Estrogen influences CLOCK (When estrogen levels are low, this positive influence diminishes, potentially leading to lower CLOCK expression or less robust CLOCK activity) Or think about how old people can never sleep well
2) CLOCK Influences ERa Expression
So a poor CLOCK means less ERa
3) CLOCK also can do something (bind? fold?) to ERa making it more efficient

As ambient light diminishes, melatonin production rises, which in turn optimally phases CLOCK gene activity, leading to increased expression and enhanced binding efficiency of Estrogen Receptor alpha (ERα), thereby allowing estrogen to effectively orchestrate crucial nighttime cellular processes like repair, apoptosis, and everything else.

So an example:
poor 5-HTP production => low serotonin
poor SAM production => critical for last step of melatonin synthesis
Less CLOCK expressions => less of all of the above estrogen stuff

So options include 5-HTP, Magnesium, SAM, Melatonin, (L-Theanine, Glycine :t_rex: to help put the body is a sleepy state)

Not sure what the evolutionary advantage is here. I usually pass out and know within a few seconds it will happen, almost never get drowsy, so I get to think a lot more?

Actionable:
We know almost alll trans folks have reduced SAM so from a general perspective, a bcomplex is the first step to improve the SAM precursor.

Will has never really commented that I remember, but I am guessing Insomnia is about equal do the SAM, but maybe slightly higher in trans women due to variants to reduce ERa such as CLOCK