Mayers-Powers, MTHFR, & Sexual Orirtentaion Changes¶
by u/Sxpunx · 22 points · 8 comments · source
A year and a half ago I read a post here about MTHFR gene mutation (confirmed I had this) and some of the symptoms of Meyer-Powers. I wish I had gotten a baseline homocysteine lab done when I started but I didn’t. (Around 6 months in I did have this tested and my levels were in the middle of normal.)
I decided to start taking L-Methylfolate 400mcg daily in the morning to see if I would notice any effects.
At first, I noticed at the 4/6-week mark that I did have increased energy. I also started taking methyl b12 at the same time so this could be a result of that.
My exercise stamina has always been pretty low and I also noticed around this time that it had started to improve. I also noticed that I seemed to be less “distracted” during the day. I think the increase focus has helped with exercise as I typically find it boring.
I am also extremely hyper-mobile with my arms and that has changed a bit. I used to do “a creepy arm stretch” and now doing that motion to stretch actually hurts.
The biggest change that I noticed and this is where it gets ---weird--- is the last 6 months or so my sexual attractions have started to evolve. I’m a 40 years old cis-male and my entire life I’ve been attracted solely to other men. Almost always it's men who are more of the bearish type. I’ve always said I’m a big man enjoyer. (I’ve identified as gay since I was 15 years old.)
This has changed and I’ve started to feel an attraction to women as well as men. I don’t know how to feel about this because… it's strange. I wonder if something with this has increased my sex drive (it has increased) or has something changed? That’s where I am at right now.
I decided recently to identify as Pansexual because that’s where I’m headed. I’m happily married to another man for and my feelings and attraction haven’t changed for him but I’m now noticing other body types I normally wouldn’t have even paid any attention to before. I almost feel like a teenager again when it comes to these attractions.
I know I’ve had friends who transitioned and had orientation shifts but this is really something I wasn’t prepared to deal with and it has been interesting.
I just wanted to share my thoughts on this as a non-scientist and see if this has happened to anyone else.
Archived 2026-04-20 from https://www.reddit.com/r/DrWillPowers/comments/1gvvyqz/mayerspowers_mthfr_sexual_orirtentaion_changes/ via arctic-shift (post was deleted/removed on Reddit).